ACE-031 (1mg) Peptide – Premium Research Agent for Muscle Growth Studies

ACE-031, also known as Ramatercept, is a recombinant fusion protein consisting of the extracellular domain of the human activin receptor type IIB (ActRIIB) linked to the Fc region of human immunoglobulin G1 (IgG1) . As a myostatin inhibitor, it functions as a ligand trap that binds to myostatin and other negative regulators of muscle mass, effectively neutralizing their inhibitory effects on skeletal muscle growth.

ACE-031 Peptide (ActRIIB-IgG1) – 1mg Research Vial

Key Factual Details

Mechanism of Action & Research Applications

ACE-031 is a soluble form of the activin receptor type IIB that acts by binding to myostatin and other negative regulators of muscle mass . By sequestering these inhibitors, ACE-031 promotes muscle growth signaling pathways and supports increases in lean body mass .

Primary Research Applications:

• Muscle Growth Studies: Investigates the blockade of myostatin and activin A to support skeletal muscle mass and function 

• Muscle Wasting Models: Explores therapeutic potential for conditions involving loss of skeletal muscle mass, strength, and integrity 

• Signal Transduction Research: Examines SMAD signaling pathways downstream of myostatin inhibition 

• Protein Interaction Studies: Characterizes binding dynamics between myostatin and ActRIIB receptors 

• In Vitro Muscle Modeling: Simulates altered myostatin environments to study muscle hypertrophy and atrophy 

Research Dosing & Handling

All dosages are for in-vitro and preclinical research use only and not for human consumption.

Documented Research Parameters (Human Studies):

• Single Dose Range: 0.02 mg/kg to 3 mg/kg subcutaneously 

• Study Regimens: Doses administered once every 2 to 4 weeks 

• Pharmacokinetics: Mean T₁/₂ of 10–15 days; AUC and Cmax increased linearly with dose 

Observed Effects in Research:

• 3.3% increase in total body lean mass (DXA) at day 29 in the 3 mg/kg group 

• 5.1% increase in thigh muscle volume (MRI) at day 29 in the 3 mg/kg group 

• Significant increase in body weight and lean body mass in non-human primate models over 14 weeks 

Storage:

• Store lyophilized powder at -20°C

• For reconstituted solutions: store at -80°C for long-term stability